Generation of a Matrix Gla (Mgp) floxed mouse, followed by conditional knockout, uncovers a new Mgp function in the eye
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چکیده
منابع مشابه
Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone.
As part of its catabolic action in bone, parathyroid hormone (PTH) inhibits extracellular matrix mineralization. We previously showed that PTH dose-dependently induces matrix gla protein (MGP) expression in osteoblasts and this induction is at least partially responsible for PTH-mediated inhibition of mineralization. Recently, we identified PKA and ERK/MAPK as the key signaling pathways involve...
متن کاملScoring of Matrix Gla protein (MGP) promoter variants within predicted transcription elements
Background: Matrix Gla protein (MGP) is known as a calcium scavenger within sub-endothelial space of vessels, so that its function is suggested to reduce the risk of coronary artery diseases. In this study, we predicted the role of MGP promoter rs1800801, rs1800802 and rs1800799 variants on the score changes of predicted transcription elements. Methods: The gene promoter fragments flanking the ...
متن کاملPolymorphisms of the human matrix gla protein (MGP) gene, vascular calcification, and myocardial infarction.
The matrix Gla protein (MGP) is an important inhibitor of vessel and cartilage calcification that is strongly expressed in human calcified, atherosclerotic plaques and could modulate plaque calcification and coronary heart disease risk. Using a genetic approach, we explored this possibility by identifying polymorphisms of the MGP gene and testing their possible association with myocardial infar...
متن کاملMatrix Gla-Protein (MGP) Not Only Inhibits Calcification in Large Arteries But Also May Be Renoprotective: Connecting the Dots
Article history: Received 19 January 2016 Accepted 19 January 2016 Available online 21 January 2016 cardiovascular outcomes, and mortality (Liu et al., 2015). MGP acts as a strong inhibitor of soft tissue calcification. As an illustration, MGP knockout mice develop massive vascular calcification in their first weeks of life and die within 2 months of vessels' rupture (Luo et al., 1997). To acqu...
متن کاملGeneration and Validation of a Mouse Line with a Floxed SRC-3/AIB1 Allele for Conditional Knockout
The steroid receptor coactivator-3 (SRC-3), also known as AIB1, ACTR, p/CIP and NCOA3, is a transcriptional coactivator for nuclear receptors and certain other transcription factors. SRC-3 is widely expressed and plays important physiological functions and pathogenic roles in breast and prostate cancers. SRC-3 knockout (SRC-3(-/-)) mice display genetic background-dependent embryonic lethality a...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-75031-7